Construction and Packaging Service of virus Vector
Construction and Packaging Services of AAV
Large scale AAV production
Serotype | Tropism |
---|---|
AAV1 | Muscle, heart, CNS, RPE, lung, skeletal muscle |
AAV2 | In vitro, CNS, RPE, muscle, liver,CNS |
AAV5 | Lung, RPE, CNS, pancreas, adipose, liver |
AAV6 | Muscle, lung, heart |
AAV8 | Liver, muscle, RPE, CNS, adipose, pancreas |
AAV-pan | Pancreas |
AAV9 | Lung, liver, muscle, heart, CNS, adipose, BBB |
AAV.rh10 | CNS, BBB, pleura |
AAV-Rec2 | Adipose |
AAV.DJ | In vitro, liver, heart, kidney |
AAV2/RETRO | Retro |
AAV.PHP.S | DRG, heart, colon |
AAV.PHP.B | BBB |
AAV.PHP.eB | BBB |
NO. | Name | Characteristics | Size(bp) |
---|---|---|---|
Strong promoters | |||
1 | CMV | Ubiquitous | 584 |
2 | CAG | Ubiquitous | 1678 |
3 | CBA( Cbh ) | Ubiquitous | 793 |
4 | n Ef1α | Short Ef1α,Ubiquitous | 493 |
5 | Ef1α | Ubiquitous | 1179 |
6 | hUbC | Ubiquitous | 1130 |
Inducible promoters | |||
1 | TRE3G | Tetracycline(Tet)-inducible | 350 |
Activity–dependent promoters | |||
1 | C-fos | Immediate-early gene promoter | 662 |
2 | E-SARE | Enhanced synaptic activity–responsive element | 954 |
Neuron-specific promoters | |||
1 | Mecp2 | Truncated Mcep2 neuron specific | 230 |
2 | hSyn | Mature neuron specific | 485 |
3 | CaMKIIa | Specific expression inexci-tatory neurons in the neocortex and hippocampus | 1293 |
4 | PV | GABAergic neuron subtypes | 2396 |
5 | SST | GABAergic neuron subtypes | 2597 |
6 | VGAT | GABAergic neuron | 1800 |
7 | mDlX | GABAergic neuron | 530 |
8 | TH | Dopaminergic neuron specific | 299 |
9 | TPH2 | Tryptophan hydroxylase promoter | 2042 |
10 | ChAT | Cholinergic neuron specific | 1500 |
11 | GFAP | Astrocyte specific | 2207 |
12 | GFAP104 | Short GFAP | 845 |
13 | Cx30(GJB6) | Astrocyte specific | 1505 |
14 | CX3CR1 | Microglia specific | 1263 |
15 | Mash1/Ascl1 | Neural stem cell specific | 1469 |
16 | Nestin | Neural stem cell specific | 1394 |
17 | L7/Pcp2 | Purkinje cell | 990 |
18 | MBP | Myelin basic protein promoter, efficient transduction of oligodendrocytes | 1300 |
19 | TRPV1 | Transient receptor potential cation channel, subfamily V, member 1 | 2073 |
20 | TRPV2 | Transient receptor potential cation channel, subfamily V, member 2 | 1700 |
21 | D1 | D1 dopamine receptor | 827 |
22 | D2 | D2 dopamine receptor | 1211 |
23 | OT | Oxytocin promoter | 2612 |
24 | CRH | Corticotropin-Releasing Hormone (CRH) promoter | 456 |
25 | PTH | Human parathyroid hormone promoter | 925 |
Eye-specific promoters | |||
1 | hGRK1 | Human rhodopsin kinase promoter | 292 |
2 | CAR | Cone arrestin gene promoter | 523 |
3 | Grm6 | Bipolar cell specific expression | 200 |
4 | mRHOP | Rhodopsin gene promoter | 524 |
5 | ROH | Rhodopsin gene promoter | 2200 |
6 | Nrl | Neural retina leucine zipper gene promoter | 3200 |
7 | RK | Rhodopsin kinase promoter | 295 |
Liver-specific promoters | |||
1 | ALB | Albumin enhancer promoter | 1001 |
2 | TBG | Serine (or cysteine) peptidase inhibitor, clade A | 410 |