Adeno-Associated Virus (AAV)| BrainVTA

Adeno-Associated Virus (AAV)

Adeno-associated virus (AAV) was discovered in 1965, as a contaminant of adenovirus (Ad) preparations, hence the name. It is replication-defective, non-enveloped small viruses (20nm) with a genome of single stranded DNA, from the parvovirus family. As 80-90% of humans are sero-positive with AAV2, most people treated with AAVs are non-pathogenic. Recombinant AAVs can infect both dividing and non-dividing cells and persist in an extrachromosomal state without integrating into the genome of the host cell.

How do I obtain virus packaging services?
BrainVTA provide professional，convenient and R & D products experienced service of AAV, ranging from small-scale to the large-scale, which help scientist accelerate the research process in circuit tracing, mechanisms of disease and treatment of disease.
So far, we have nearly 1000 pre-made AAV products with different serotypes and promoters. Meanwhile, we have offered 2000 customized AAV services for our clients with the following serotypes: AAV-1, AAV-2, AAV-5, AAV-6, AAV-8, AAV-DJ, AAV-PHP.eB, AAV-retro, AAV-anc80 and AAV-9. Artificially designed serotypes and vectors also can be produced on a case-by-case basis.
Please click Pre-Made AAVs for the in stock AAVs.
By clicking here for Custom-Made AAVs service.

Virus serotypes

BrainVTA currently offers the following serotypes: 1, 2, 5, 6, 8, 9, rh10, DJ, DJ8, PHP.B, PHP.eB, PHP.S, retro, pan, anc80. Novel peptide modified serotypes can also be produced on a case-by-case basis. Tissue specificity is determined by the serotype. If you Don't know which AAV serotype to use, see the following table to explore available AAV serotype to meet the efficient delivery of gene into the cells or tissues of interest.

Serotype	Tropism
AAV1	Muscle, heart, CNS, RPE, lung, skeletal muscle
AAV2	In vitro, CNS, RPE, muscle, liver,CNS
AAV5	Lung, RPE, CNS, pancreas, adipose, liver
AAV6	Muscle, lung, heart
AAV8	Liver, muscle, RPE, CNS, adipose, pancreas
AAV-pan	Pancreas
AAV9	Lung, liver, muscle, heart, CNS, adipose, BBB
AAV.rh10	CNS, BBB, pleura
AAV-Rec2	Adipose
AAV.DJ	In vitro, liver, heart, kidney
AAV2/RETRO	Retro
AAV.PHP.S	DRG, heart, colon
AAV.PHP.B	BBB
AAV.PHP.eB	BBB

Tissue-specific promoters
BrainVTA offers various tissue-specific promoters. Listed below are the most commonly chosen promoters. Don' see the promoter of interest, Please inquire.

NO.	Name	Characteristics	Size（bp）
Strong promoters
1	CMV	Ubiquitous	584
2	CAG	Ubiquitous	1678
3	CBA( Cbh )	Ubiquitous	793
4	n Ef1α	Short Ef1α,Ubiquitous	493
5	Ef1α	Ubiquitous	1179
6	hUbC	Ubiquitous	1130
Inducible promoters
1	TRE3G	Tetracycline(Tet)-inducible	350
Activity–dependent promoters
1	C-fos	Immediate-early gene promoter	662
2	E-SARE	Enhanced synaptic activity–responsive element	954
Neuron-specific promoters
1	Mecp2	Truncated Mcep2 neuron specific	230
2	hSyn	Mature neuron specific	485
3	CaMKIIa	Specific expression inexci-tatory neurons in the neocortex and hippocampus	1293
4	PV	GABAergic neuron subtypes	2396
5	SST	GABAergic neuron subtypes	2597
6	VGAT	GABAergic neuron	1800
7	mDlX	GABAergic neuron	530
8	TH	Dopaminergic neuron specific	299
9	TPH2	Tryptophan hydroxylase promoter	2042
10	ChAT	Cholinergic neuron specific	1500
11	GFAP	Astrocyte specific	2207
12	GFAP104	Short GFAP	845
13	Cx30（GJB6)	Astrocyte specific	1505
14	CX3CR1	Microglia specific	1263
15	Mash1/Ascl1	Neural stem cell specific	1469
16	Nestin	Neural stem cell specific	1394
17	L7/Pcp2	Purkinje cell	990
18	MBP	Myelin basic protein promoter, efficient transduction of oligodendrocytes	1300
19	TRPV1	Transient receptor potential cation channel, subfamily V, member 1	2073
20	TRPV2	Transient receptor potential cation channel, subfamily V, member 2	1700
21	D1	D1 dopamine receptor	827
22	D2	D2 dopamine receptor	1211
23	OT	Oxytocin promoter	2612
24	CRH	Corticotropin-Releasing Hormone (CRH) promoter	456
25	PTH	Human parathyroid hormone promoter	925
Eye-specific promoters
1	hGRK1	Human rhodopsin kinase promoter	292
2	CAR	Cone arrestin gene promoter	523
3	Grm6	Bipolar cell specific expression	200
4	mRHOP	Rhodopsin gene promoter	524
5	ROH	Rhodopsin gene promoter	2200
6	Nrl	Neural retina leucine zipper gene promoter	3200
7	RK	Rhodopsin kinase promoter	295
Liver-specific promoters
1	ALB	Albumin enhancer promoter	1001
2	TBG	Serine (or cysteine) peptidase inhibitor, clade A	410

Ready to order?
Know what you need? Just click the Pre-Made AAVs or theCustom-Made AAVs Button and submit your needs to us.

Return to top